In this paper, I analyze digital games in their fundamental role as cognitive artifacts that promote new ways of formulating knowledge in collaborative communities. To illustrate these concepts, I analyze Foldit, a digital game whose main objective is for players to map protein folding through a series of puzzles. The data generated by players is analyzed by scientists and incorporated into actual research. Digital games can be powerful tools to generate new knowledge in collaborative communities of players, by joining the computational power of digital games and the creative problem-solving skills of engaged players.